49ers RB Depth Chart: Isaac Guerendo To Take Over After Latest Christian McCaffrey, Jordan Mason Injuries

## 49ers RB Depth Chart: Isaac Guerendo To Take Over After Latest Christian McCaffrey, Jordan Mason Injuries

### McCaffrey's Lingering Calf Issue

### Mason's Ankle Sprain

### Enter Isaac Guerendo

With McCaffrey and Mason sidelined, Guerendo is expected to take on a larger role in the 49ers' offense. The 24-year-old running back has primarily been used on special teams and as a depth option behind McCaffrey and Mason.

### Implications for Week 16

The 49ers will need Guerendo to step up in a big way if they want to maintain their offensive efficiency. The Commanders' defense has been allowing an average of 134.0 rushing yards per game, which is the fifth-highest in the NFL.

### Long-Term Outlook

The 49ers are cautiously optimistic that McCaffrey will be able to return in time for the playoffs. However, there is no guarantee that he will be 100% healthy, and Guerendo could continue to play a significant role even if McCaffrey returns.

Guerendo's performance in the coming weeks could determine his future with the 49ers. If he impresses, he could earn a more prominent role in the offense beyond this season.

### Conclusion

The 49ers' running back depth chart has been hit hard by injuries. Isaac Guerendo is expected to take over as the lead running back in Week 16, and his performance could have implications for both the immediate and long-term future of the 49ers' offense.